CBD Oil Could be the Ingredient Missing in your Skincare Routine

The human endocannabinoid system (ECS) is involved in the modulation of cutaneous (skin) biology. ECS Receptors, known commonly as cannabinoid receptors, have been identified in the skin. Misuse of synthetic cannabinoids (ex: Delta-8) has also been associated with the manifestation of dermatological disorders, indicating the pertinent effects of the endocannabinoid system on skin biology.

Preclinical evidence suggests that topical application of CBD products may be beneficial for skin disorders such as eczema, psoriasis, pruritus (itching) , and other inflammatory conditions. However, confirmed clinical efficacy and the underlying molecular mechanisms of CBD on cosmetic improvement have yet to be fully identified.

Interestingly, cannabinoid receptors exist throughout our bodies; research indicates that both Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) receptors are found in epidermal keratinocytes, cutaneous nerve fibers, dermal cells, melanocytes, eccrine sweat glands, and hair follicles. Endocannabinoids are involved in a variety of skin functions, such as formation & maintenance of the skin barrier, cell growth & differentiation, and certain immunological & inflammatory processes.

Because the ECS plays an important regulatory function in the skin, it is reasonable to suggest that treatment with topical cannabinoids could be efficacious for certain disorders, or for skin health in general. Not surprisingly, there is lacking research investigating the therapeutic potential for topical applications of cannabinoids. Historically, there is evidence to suggest applying CBD topically may be a viable route of administration for certain skin conditions. For example, researchers previously investigated the efficacy of CBD Gel (1–10%) in reduction of inflammation-associated symptoms in a monoarthritic rat model, and found that it was well absorbed - the plasma concentration directly correlated with the dose applied (dose-dependent reaction). As of 2021, no clinical trials investigating the topical absorptive capability of CBD in humans had been identified. Further work is warranted to better understand the appropriate doses and delivery methods for therapeutic CBD skin applications.

The authors of the conclude that while there is absolutely promising potential for CBD in the treatment of acne, seborrhea, eczema/dermatitis, and improvement of skin barrier function, larger and more structured studies are needed to fully validate its efficacy.

Note from the Author:

This is a reiteration of an article I had written as an APPE Pharmacy Student back in 2021. The reason I initially wrote this article is because I had been gifted CBD/Hemp Oil in 2020, and was able to have firsthand experience of the effect it had on my skin. Although I didn't find the systemic effects (anxiety reduction, sleep improvement) to be particularly noticeable, my skin became clearer for longer than it had ever been before. Aside from a sensitive cleanser, CBD/hemp oil was the only product I needed in my skincare routine circa 2020. All I had to do was apply a small amount to my face daily after showering. I found that the CBD/Hemp Oil (I wish I remembered the brand!) was moisturizing and absorbed well - no oily residue! As I'm revisiting this skin hack of my past, I'm wondering -- why did I ever stop using it? As a sufferer of adult hormonal acne, I might just have to pick up another bottle...

Resources:

2)LaStella A. Therapeutic Potential of CBD Oil for Skin Health and Disorders. The SocioEsthetician International. https://www.the-socioesthetician-international.com/forum/pharm-d-candidate-appe/therapeutic-potential-of-cbd-oil-for-skin-health-and-disorders. Published 04/29/2021. Last Updated 04/29/2021.